Each portable INR monitor works slightly differently, but they are all quite simple to use.
The basic testing procedure is
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Insert a test strip into the machine.
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Apply a fresh drop of blood from a finger prick to the test strip.
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The machine will perform the INR test.
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The INR result is displayed on the screen.
For example, click here for a diagram of how to use the CoaguChek XS®.
Each manufacturer provides information on their monitors and the benefits each offers.
Roche have provided an animated demonstration of the self-monitoring procedure using the Coaguchek XS® device here:
http://coaguchek.com/flash/animation/coaguChek_xs_patient.html
You can find information on the Hemosense INRatio® device here:
http://www.hemosense.com/patient/inratio.shtml